The Hicobox unit has been designed for applications in which the process environment operates at a lower working pressure than the surrounding area. In such situations, without a Hicobox in place, the flexible bags can collapse as a result of the negative differential pressure. This, in turn, prevents material (tablets) from flowing into the Hicoflex® Bag. The Hicobox completely encapsulates the Hicoflex® Adapter, Hicoflex® Bag and the Hicoflex® Pneumatic Opening Tool and is put under the same pressure as the process area. This eliminates the pressure differential and guarantees material flow.